Two primary factors set OxyContin abuse apart from other prescription drug abuse: OxyContin abusers often crush the tablet and ingest or snort it, or dilute it in water and inject it. Both methods lead to the rapid release and absorption of Oxycodone.

Crushing or diluting the tablet disarms the timed-release action causing rapid release of a 12-hour supply of the drug resulting in a quick, powerful high. Abusers have compared this feeling to the euphoria they experience when taking heroin.

OxyContin is obtained for illicit purposes though theft, including stealing from someone with a legitmate prescription, prescription forgetry, doctor shopping (with or without legitimate ailments), and improper prescribing.

Studies done by the Drug Abuse Warning Network (DAWN) show that there has been an increase in the abuse of Oxycodone products over the past three years.